A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy
Identifieur interne : 000844 ( Main/Exploration ); précédent : 000843; suivant : 000845A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy
Auteurs : Anette Schrag [Royaume-Uni] ; Shamira Sheikh [Royaume-Uni] ; Niall P. Quinn [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Caroline Selai [Royaume-Uni] ; Chris Mathias [Royaume-Uni] ; Irene Litvan [États-Unis] ; Anthony E. Lang [Canada] ; James H. Bower [États-Unis] ; David J. Burn [Royaume-Uni] ; Philip Low [États-Unis] ; Marjan Jahanshahi [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-06-15.
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Abstract
The objective of this study was to compare subjective health status and its correlates in progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). One hundred eighty‐eight patients with PSP and 286 patients with MSA completed EQ‐5D and Hospital Depression and Anxiety Scale. The impact on mobility, usual activities, and self‐care was similarly high in both groups after similar duration. Fifty‐six percent of PSP and 43% of MSA had probable depression, and 37% of both groups had probable anxiety. Patients with PSP had significantly higher depression scores, but groups did not differ in anxiety scores. Patients with MSA had significantly greater pain/discomfort than patients with PSP. The most important association with subjective health status was with depressive symptoms, which accounted for 38% and 29% of EQ‐5D variance in patients with PSP and MSA, followed by disease severity and anxiety scores. We conclude that depressive symptoms were common in both disorders, but more severe in PSP. Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22794
Affiliations:
- Canada, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Kentucky, Minnesota, Ontario
- Londres, Toronto
- National Hospital for Neurology and Neurosurgery, Université de Toronto
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-06-15">2010-06-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1077">1077</biblScope><biblScope unit="page" to="1081">1081</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D8D7BC0907EA1442286D43654D717164271E4C8E</idno><idno type="DOI">10.1002/mds.22794</idno><idno type="ArticleID">MDS22794</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>anxiety</term><term>depression</term><term>health status</term><term>multiple system atrophy</term><term>parkinsonism</term><term>progressive supranuclear palsy</term><term>quality of life</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to compare subjective health status and its correlates in progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). One hundred eighty‐eight patients with PSP and 286 patients with MSA completed EQ‐5D and Hospital Depression and Anxiety Scale. The impact on mobility, usual activities, and self‐care was similarly high in both groups after similar duration. Fifty‐six percent of PSP and 43% of MSA had probable depression, and 37% of both groups had probable anxiety. Patients with PSP had significantly higher depression scores, but groups did not differ in anxiety scores. Patients with MSA had significantly greater pain/discomfort than patients with PSP. The most important association with subjective health status was with depressive symptoms, which accounted for 38% and 29% of EQ‐5D variance in patients with PSP and MSA, followed by disease severity and anxiety scores. We conclude that depressive symptoms were common in both disorders, but more severe in PSP. Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Kentucky</li><li>Minnesota</li><li>Ontario</li></region><settlement><li>Londres</li><li>Toronto</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li><li>Université de Toronto</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name></region><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Mathias, Chris" sort="Mathias, Chris" uniqKey="Mathias C" first="Chris" last="Mathias">Chris Mathias</name><name sortKey="Mathias, Chris" sort="Mathias, Chris" uniqKey="Mathias C" first="Chris" last="Mathias">Chris Mathias</name><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><name sortKey="Selai, Caroline" sort="Selai, Caroline" uniqKey="Selai C" first="Caroline" last="Selai">Caroline Selai</name><name sortKey="Sheikh, Shamira" sort="Sheikh, Shamira" uniqKey="Sheikh S" first="Shamira" last="Sheikh">Shamira Sheikh</name></country><country name="États-Unis"><region name="Kentucky"><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name></region><name sortKey="Bower, James H" sort="Bower, James H" uniqKey="Bower J" first="James H." last="Bower">James H. Bower</name><name sortKey="Low, Philip" sort="Low, Philip" uniqKey="Low P" first="Philip" last="Low">Philip Low</name></country><country name="Canada"><region name="Ontario"><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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